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Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma.

van Dijk BA, Schouten LJ, Oosterwijk E, Hulsbergen-van de Kaa CA, Kiemeney LA, Goldbohm RA, Schalken JA, van den Brandt PA

Department of Epidemiology, NUTRIM, Maastricht University, PO Box 616, Maastricht 6200 MD, The Netherlands.

We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations.

Published 7 August 2006 in Br J Cancer, 95(3): 374-7.
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